On Sunday, a U.S. drone strike in northern Yemen killed four senior Isis leaders, including a top Isis leader in the country’s eastern province of Shabwa.
The strikes came days after the United States and Saudi Arabia announced an offensive to retake the southern city of Mukalla from the militant group.
Isis fighters have been pushing toward Shabawa in recent weeks.
In a separate attack in March, more than 70 civilians were killed when a U-Haul truck carrying suspected Isis fighters and equipment was ambushed and hit by a Saudi-led coalition airstrike.
A total of 832 civilians and civilian infrastructure were killed in the attack.
The U.N. says the Saudi-backed offensive in Shabawar has displaced more than 500,000 people.